Understanding the release behavior of folic acid through liquid-crystalline folate nanoparticles: Process optimization through Response-Surface methodology and Mathematical modeling using Noyes-Whitney approach

In our previous studies we have shown the potential of folate nano-carriers in releasing the encapsulated chemotherapeutic drugs at controlled rates. Also, we have seen that the release rates of encapsulated drugs and the carrier (folic acid) are comparable and can be regulated by different design parameters like particle size and cross-linking. To achieve different release rates, the design parameters have to be optimized. Therefore, we need to understand how different factors simultaneously affect the release behavior of folic acid (and/or drugs). With the use of Response-surface methodology approach, this article understands the combined effect of different factors affecting the release behavior and optimizes different parameters to obtain desired folic acid release. Also, with the help of drug dissolution model, the present article understands the mechanism of release behavior and the role of design parameters in controlling the release rates.